phenobarbital raises toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers could raise the metabolism of ifosfamide to its Energetic alkylating metabolites.Prevent; coadministration with CYP3A inducers may cause diminished plasma concentrations of elvitegravir and/or perhaps a concomitan